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What is Glycine? Are You Getting enough and Where to Find the Best Sources?

28 October 2024
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Glycine, the simplest amino acid, is critical in maintaining overall health. Here's a breakdown of its functions across various systems:

 

Critical Roles of Glycine in Health

 

1. Collagen Production and Connective Tissue Support

   - Glycine is a major component of collagen, contributing to skin elasticity, joint health, and tissue repair. Around 33% of collagen comprises Glycine, which helps maintain the structural integrity of connective tissues.

 

2. Sleep Regulation

   - Glycine promotes relaxation and sleep by acting on neurotransmitter receptors in the brain. It lowers core body temperature, improves sleep quality, and helps reduce insomnia symptoms.

 

3. Anti-inflammatory and Antioxidant Properties

   - Glycine supports the synthesis of glutathione, a powerful antioxidant that helps combat oxidative stress. It also reduces inflammatory markers, benefiting people with chronic inflammatory conditions.

 

4. Neurotransmitter Function

   - Glycine acts as an inhibitory neurotransmitter in the brain and spinal cord, reducing excitability and promoting calmness. It plays a role in preventing neurological disorders such as epilepsy.

 

5. Metabolic and Digestive Health

   - It aids in producing bile salts and stomach acid, improving digestion. Glycine is also involved in gluconeogenesis, helping maintain blood sugar levels by creating glucose when necessary.

 

6. Muscle Health and Repair

   - Glycine is essential for muscle protein synthesis and helps prevent muscle breakdown, benefiting athletes and individuals recovering from injuries or surgeries.

 

7. Cardiovascular Health

   - Glycine improves circulation and supports cardiovascular function by enhancing nitric oxide availability, which relaxes blood vessels and lowers blood pressure.

 

8. Immune System Support

   - Glycine enhances immune function by supporting white blood cell activity and maintaining a healthy inflammatory response.

 

Summary of Benefits

 

Glycine plays diverse roles in maintaining joint and skin health, promoting better sleep, supporting cognitive and digestive functions, and reducing inflammation. This amino acid is critical for collagen synthesis, detoxification processes, and muscle repair, making it an essential nutrient in the body's structural and metabolic health.

 

Where Can I get Glycine from?

 

You can find Glycine in hydrolyzed collagen supplements, but just be sure your collagen is free from Glyphosate. Ensure it is tested, and the company isn't just saying it's free from Glyphosate but that they can provide evidence. Perfect Supplements Hydrolyzed collagen can give you that assurance. We can provide you with that assurance right here.

 

Glycine can also be found in meat, fish, bone broth, gelatin, and some plant sources. It is most abundant in gelatin and collagen supplements or foods high in these.

 

What about Glyphosate?

 

Glyphosate, the active ingredient in many herbicides like RoundUp, is chemically similar to the amino acid glycine. Specifically, it has a phosphonomethyl group attached to the nitrogen atom of Glycine, leading to concerns that Glyphosate may interfere with biological processes involving Glycine.

 

How Glyphosate Mimics Glycine

Due to their structural similarity, Glyphosate can be a substitute for Glycine in protein synthesis. Since Glycine is critical for proteins that require flexibility and stability (like collagen and neurotransmitter receptors), Glyphosate's substitution might impair these functions. This could result in proteins adopting incorrect shapes or malfunctioning, leading to adverse health outcomes.

 

Potential Negative Health Effects of Glyphosate Substitution

1. Neurological Disorders: Substitution of Glycine in essential proteins might disrupt neurotransmitter systems, contributing to neurological conditions like Parkinson's, Alzheimer's, and autism.

2. Inflammation and Metabolic Disorders: Disruption in proteins involved in metabolic regulation may increase the risk of obesity, diabetes, and cardiovascular issues.

3. Gut Health Issues: Glyphosate negatively affects beneficial gut bacteria, potentially leading to inflammatory bowel conditions and impaired digestion.

4. Cancer Risk: Studies have shown correlations between glyphosate exposure and an increased incidence of certain cancers, such as non-Hodgkin's lymphoma.

 

The list goes on and on. Please read our detailed blog about Glyphosate and health here.

 

Conclusion

While more research is needed to fully understand the biochemical implications of Glyphosate acting as a glycine analogue, the evidence suggests that this substitution can interfere with normal protein function. This interference may contribute to various chronic health issues, highlighting the importance of monitoring glyphosate exposure in food and the environment.

 

References:

https://academic.oup.com/toxsci/article/192/2/131/7066927?login=false

https://people.csail.mit.edu/seneff/2016/Glyphosate_V_glycine_analogue_2016.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC10379184/

 

Disclaimer: The information in this article is intended purely as information and not health advice. It is not intended to treat, diagnose, prevent, or cure, and one should always seek expert advice from their trusted health practitioner. 

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